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Uniform switching behavior of HfOx-based memory with gradual-grown filaments by interface modulation

HfOx/Cu/HfOx structures with Ti electrodes were fabricated to investigate the resistive switching characteristics. Stable and uniform switching behaviors can be observed for HfOx/Cu/HfOx sample except the few cycles at the beginning. XPS depth profile of the structure was carried out to explore the role of interface layer on chemical composition of HfOx film and the defects in the films were analyzed. In addition, the resistance in LRS was insensitive to device area. The processes of growth and dissolution of conductive filaments in HfOx film during switching cycles were investigated. The undissolved filaments in the bottom part of HfOx film promoted the growth of filaments in the subsequent set process. As the fixed Vos filaments and stable residual Cu filaments which can act as a precursor in upper and bottom part of the sample were formed, excellently uniform distribution of switching parameters can be obtained. Meanwhile, good endurance and retention properties can be observed for HfOx/Cu/HfOx sample. The migration of Vos and diffusion of Cu atoms under electric field were both responsible for the resistive switching behavior for HfOx/Cu/HfOx sample, and the underlying physical model of conductive filaments was proposed to illustrate the switching mechanism of HfOx/Cu/HfOx sample.

Vacuum EI,SCI,SCIE | 2021 | 189

Parameter estimation in fuzzy partial univariate linear regression model with non-fuzzy inputs and triangular fuzzy outputs

This paper proposed an extension for the classical partial univariate regression model with non-fuzzy inputs and triangular fuzzy output. For this purpose, the popular non-parametric estimator and the conventional arithmetic operations of triangular fuzzy numbers were combined to construct a fuzzy univariate regression model. Then, a hybrid algorithm was developed to estimate the bandwidth and fuzzy regression coefficient. Some common goodness-of-fit criteria were also used to examine the performance of the proposed method. The effectiveness of the proposed method was then illustrated through two numerical examples including a simulation study. The proposed method was also compared with several common fuzzy linear regression models with exact inputs and fuzzy outputs. Compared to the available fuzzy linear regressions models, the numerical results clearly indicated that the proposed fuzzy regression model is capable of exhibiting more accurate performances.

IRANIAN JOURNAL OF FUZZY SYSTEMS SCIE | 2021 | 18 (2)

Hypofractionated frameless gamma knife radiosurgery for large metastatic brain tumors

Hypofractionated stereotactic radiosurgery has become an alternative for metastatic brain tumors (METs). We aimed to analyze the efficacy and safety of frameless hypofractionated Gamma Knife radiosurgery (hfGKRS) in the management of unresected, large METs. All patients who were managed with hfGKRS for unresected, large METs (> 4 cm3) between June 2017 and June 2020 at a single center were reviewed in this retrospective study. Local control (LC), progression-free survival (PFS), overall survival (OS), and toxicities were investigated. A total of 58 patients and 76 METs with regular follow-up were analyzed. LC rate was 98.5% at six months, 96.0% at one year, and 90.6% at 2 years during a median follow-up of 12 months (range, 2–37). The log-rank test indicated no difference in the distribution of LC for any clinical or treatment variable. PFS was 86.7% at 6 months, 66.6% at 1 year, and 58.5% at 2 years. OS was 81% at 6 months, 63.6% at one year, and 50.7% at 2 years. On the log-rank test, clinical parameters such as control status of primary cancer, presence of extracranial metastases, RTOG-RPA class, GPA group, and ds-GPA group were significantly associated with PFS and OS. Patients presented with grade 1 (19.0%), grade 2 (3.5%) and grade 3 (5.2%) side effects. Radiation necrosis was not observed in any patients. Our current results suggest that frameless hfGKRS for unresected, large METs is a rational alternative in selected patients with promising results.

Clinical & experimental metastasis SCI,SCIE | 2021 |

Hepatoprotective effect of Omega-3 PUFAs against acute paracetamol-induced hepatic injury confirmed by FTIR

Acute paracetamol over dose-induced hepatotoxicity is considered an important medical hazard especially among women. Omega-3 long-chain polyunsaturated fatty acids (Omega-3 PUFAs) daily doses are nowadays recommended for their antioxidant and anti-inflammatory potentials. Fourier transform infrared (FTIR) spectroscopy is considered a reliable method in analyzing cellular alterations and is now efficiently used to diagnose several diseases and the efficacy of drugs even in the early stages. The aim of our study was to evaluate the hepatoprotective effect of Omega-3 PUFAs against paracetamol-induced hepatotoxicity in rats confirmed through measuring protein alterations in hepatocytes by FTIR. Rats were pretreated with Omega-3 PUFAs (50 and 100 mg/kg) for 21 days prior to oral ingestion of paracetamol. FTIR results revealed that Omega-3 PUFAs (50 mg/kg) limited the toxic effects of paracetamol by restoring the hepatic amide I to amide II ratio. In addition; biochemical analyses demonstrated that serum ALT, AST, Cholesterol, LDL-cholesterol and Il-6 levels as well as hepatic TNF-α, MDA, NOx levels were decreased. Besides; serum HDL-cholesterol level and hepatic GSH level were increased. Histopathological examinations of hepatic sections validated the hepatoprotective potential. The overall effect of this dose was comparable to those of the usual recommended hepatoprotective supplement; silymarin. In conclusion; it would be recommended to use Omega-3 PUFAs in low doses on daily bases as a hepatoprotective agent.

Human & experimental toxicology SCI,SCIE | 2021 | 40 (3)

Treatment pathway analysis of newly diagnosed dementia patients in four electronic health record databases in Europe

Real-world studies to describe the use of first, second and third line therapies for the management and symptomatic treatment of dementia are lacking. This retrospective cohort study describes the first-, second- and third-line therapies used for the management and symptomatic treatment of dementia, and in particular Alzheimer’s Disease. Medical records of patients with newly diagnosed dementia between 1997 and 2017 were collected using four databases from the UK, Denmark, Italy and the Netherlands. We identified 191,933 newly diagnosed dementia patients in the four databases between 1997 and 2017 with 39,836 (IPCI (NL): 3281, HSD (IT): 1601, AUH (DK): 4474, THIN (UK): 30,480) fulfilling the inclusion criteria, and of these, 21,131 had received a specific diagnosis of Alzheimer’s disease. The most common first line therapy initiated within a year (± 365 days) of diagnosis were Acetylcholinesterase inhibitors, namely rivastigmine in IPCI, donepezil in HSD and the THIN and the N-methyl-d-aspartate blocker memantine in AUH. We provide a real-world insight into the heterogeneous management and treatment pathways of newly diagnosed dementia patients and a subset of Alzheimer’s Disease patients from across Europe.

Social Psychiatry and Psychiatric Epidemiology SSCI,SCIE | 2021 | 56 (3)